Antioxidative potential of Flemingia praecox in managing male infertility: A comparative study with mucuna pruriens

17^th European Biosimilars Congress

April 04-05, 2024 | Madrid, Spain

Dayanand P Gogle, Shravan D Kumbhare and Sanghadeep S Ukey

RTM Nagpur University, India Lokmanya Tilak College, India

Posters & Accepted Abstracts: J Bioanal Biomed

Abstract :

In the fight against male infertility, which accounts for half of all infertility cases, oxidative stress plays a significant role. With the limitations of synthetic antioxidants, this study explores natural solutions, specifically examining the antioxidative capabilities of Flemingia praecox, as employed by tribal populations in India, against the established Mucuna pruriens. Employing in vitro assays, this research assessed the total phenolic and flavonoid contents, alongside a spectrum of antioxidant activities (DPPH, FRAP, ABTS, DMPD) and DNA damage protection ability of both F. praecox root and M. pruriens seed extracts. The study extended to evaluate the inhibition of key male infertility enzymes, namely phosphodiesterase 5 (PDE5) and arginase, to provide additional insight into their therapeutic potential. Notably, F. praecox roots demonstrated higher total flavonoid content, DPPH radical scavenging activity, total antioxidant activity (ABTS, DMPD assays), and PDE5 enzyme inhibition. In contrast, M. pruriens seeds exhibited superior outcomes in total phenolic content, ferric-reducing power (FRAP assay), and DNA damage protection. Compared to standard synthetic antioxidants, F. praecox antioxidative activity is promising. The study concludes that F. praecox exhibits potential as an effective natural agent for combatting oxidative stress-induced male infertility, paralleled with the recognized benefits of M. pruriens. As this condition is increasingly tied to serious health issues, including metabolic disorders and hereditary implications, the results advocate for a deeper exploration into F. praecox's clinical applicability in treating male reproductive conditions. These preliminary findings could herald a new avenue for plant-based remedy development, addressing not only fertility concerns but also broader health implications associated with oxidative stress. Further in-depth and clinical investigations are needed to confirm F. praecox's usefulness and unlock its therapeutic mechanisms. Keywords: Male infertility, oxidative stress, Flemingia praecox, Mucuna pruriens, antioxidants, traditional medicine, sperm health.