Mojhgan Sheikhpour, Akram Sadeghi and Fatemeh Yazdian
Posters: J Cancer Sci Ther
Background: Streptomyces cope with osmotic stress by accumulating or de novo synthesizing of low molecular weight, highly water-soluble organicsolutes, so-called compatible solutes or osmolytes. Ectoine, 1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid and its hydroxylated derivative, 5-hydroxyectoine are two of the most commonly found osmolytesin Streptomyces. They typically are synthesized in response to increases in environmental osmolarity. But there are a few document to demonstrate potential of prevention or therapy of diseases by these group of substances. In this new research, we investigated antiproliferative action of two compatible solute Ectoine and 5- Hydroxy ectoine on a human lung cancer cell line(QU-DB). Methods: QU-DB was treated by five doses of ectoine and also hydroxyectoine at 48 h and cytotoxicity effects of these compatible solutes on cultured cell line were demonstrated by MTT assay. Finally, nuclear morphology of cells was monitored by DAPI florescent staining method. Results: It has been demonstrated that not only ectoine, but also hydroxyectoine inhibited the proliferation of QU-DB in a dosedependent fashion and both of them had cytotoxic effects on cancer cell line and induced apoptosis in them at concentration ranging between 2 mM to10 mM. Conclusion: Because compatible solutes are compliant natural products without documented toxic potential, we propose that this group of substances may be used for the treatment of lung cancer in humans instead of traditional chemotherapy.
Mojhgan Sheikhpour has completed his PhD at the age of 35 years from Tarbiat Modaress University Faculty of Biological Sciences. She is teaches and investigates in Tehran university in Iran and has published papers in reputed journals.
Cancer Science & Therapy received 5332 citations as per Google Scholar report
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi 