Apparent diffusion coefficient value In evaluating types, stages and histologic grading of cancer cervix

7^th Global Summit on Cancer Therapy

October 05-07, 2015 Dubai, UAE

Doaa Ibrahim Hasan

Zagzig University, Egypt

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Purpose: The purpose of this study is to evaluate the usefulness of apparent diffusion coefficient (ADC value) in differentiating between probably benign breast lesions and, suspicious lesions (ACR-BIRADS categories 3and 4 respectively). Patients & Methods: Breast lesions meeting study criteria were identified on dynamic contrast enhanced (DCE)-MRI examinations in 48 women over the course of the study period for 2 years. We found 27(56.2%) of the cases probably benign as their BIRADS category 3 and the remaining 21(43.7%) cases were category 4. Images were obtained with diffusion sensitizing gradients of 0 and 750mm2/s. The apparent diffusion coefficient (ADC) was calculated and correlated with the histological data. Results: The ADC values recorded a sensitivity of 97.9% and a specificity of 80%. The positive predictive value was 95.7% in differentiation between the probably benign and suspicious breast lesions. The difference in mean ADC for probably benign breast lesions (BIRADS-3, 1.45���±0.46����10�¢����3 mm2/s), and suspicious lesions (BIRADS-4, 1.06���±0.56����10�¢����3 mm2/s) was statistically significant. Conclusion: Including the ADC diffusion coefficient in the diagnostic work up of patients with indeterminate breast lesions can help in the differentiation between benign and malignant breast lesions.

Biography :

Doaa Ibrahim Hasan is currently working as Lecturer of radio diagnosis at Department of Radiology, Faculty of medicine, Zagzig University, Egypt.

Email: dididodge@yahoo.com