Application of INAA for measurements of prostatic tissue levels of chemical elements used as cancer markers

International Conference on Nuclear Chemistry

December 08-09, 2016 San Antonio, USA

Vladimir Zaichick

Medical Radiological Research Center, Russia

Posters & Accepted Abstracts: J Nucl Med Radiat Ther

Abstract :

Prostate cancer is an internationally important health problem of the man, particularly in developed countries. The aim of this exploratory study was to evaluate whether significant changes in the prostatic tissue levels of chemical elements exist in the malignantly transformed prostate. Prostatic tissue levels of Ag, Br, Ca, Co, Cr, Fe, Hg, K, Mg, Mn, Na, Rb, Sb, Sc, Se, and Zn contents were prospectively evaluated in 32 patients with benign prostatic hyperplasia (BPH) and 36 patients with prostate cancer. Intact prostates of 37 men who had died suddenly were used as the age-matched control group. Measurements were performed using non-destructive instrumental neutron activation analysis (INAA) with high resolution spectrometry of short- and long-lived radionuclides. Prostate tissue samples were divided into two portions. One was used for morphological study while the other was intended for chemical element analysis. It was found that the contents of Al, Br, Cr, Fe, Hg, Mn, Sb were significantly higher while those of Ca, Co, K, Mg, Na, Rb, Sc, Se, and Zn were significantly lower in cancerous tissues than in BPH and normal tissues. Moreover, it was shown that the chemical elements mass fractions in prostate tissue, their ratios and other combinations are very informative markers of prostate cancer.

Biography :

Email: vezai@obninsk.com