Arsenic toxicological and carcinogenic effects assessed by metabolomic profiling in clam Scrobicularia plana exposed to arsenate

10^th Global Annual Oncologists Meeting

July 11-13, 2016 Cologne, Germany

Gopmez-Ariza J L , Rodriguez-Moro G, Garcia-Barrera T and Blasco-Moreno J

Universidad de Huelva, Spain
Instituto de Ciencias Marinas de Andaluc�­a, Spain

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Arsenic is one of the most studied elements in relation to mammal toxicity. This element is a widespread pollutant in the environment found in water, soil, and air from natural and anthropogenic sources, occurring in both inorganic and organic chemical forms, which strongly differ in terms of toxicity, accumulation, and involvement of arsenic respect to metabolism of living organisms. However, the mechanism of arsenic toxicity still remains unclear, although enzymatic inhibition, impaired antioxidants metabolism and oxidative stress may play a role. Some marine organism, as bivalves, can accumulate high amounts of metals and thus easily reach concentrations that are toxic not only to themselves but also to organisms who ingest them. In the present study, the marine bivalve, Scrobicularia plana, was used as a model organism. Clams were exposed to AsV (10 and 100 �¼gâ�¢L-1) during 14 days to check the toxicological effect related to AsV exposure. For this propuse, a metabolomic analysis was carried out by direct infusion mass spectrometry to polar and lipophilic extracts in digestive glands of S. plana in positive and negative acquisition modes (ESI-/ESI+). The results show significant changes in the metabolomic profiles of S. plana by the exposure to As. In addition, analysis of polar and lipophilic extracts using positive and negative mode allows the study and characterization of a great number of possible toxicological biomarkers.

Biography :

Email: ariza@uhu.es