Aryl sulphonamide based indolo-quinazolinones as potential anticancer agent: Rational drug design studies

18^th International Conference on Medicinal Chemistry & Targeted Drug Delivery

December 06-08, 2017 Dallas, USA

Rajak H, Parmar P, Singh A, Raghuwanshi K and Veerasamy R

Guru Ghasidas University, India
AIMST University, Malaysia

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

The persuit of better anticancer drugs and the significance of indoles and quinazolines as anticancer pharmacophore, prompted us to perform the synthesis of some novel quinazolines for their anticancer activity. A series of novel indolo[2,1-b]-quinazolinone derivatives fused with aryl sulphonamide nucleus were synthesized for their anticancer activity. The chemical structures of the compounds were elucidated by spectral (IR, 1H-NMR and MS) analysis. The anticancer activities of the compounds were investigated using MCF-7 (Breast) and A-549 (Lung) cell lines. The promising results were observed and efforts were also made to accomplish structure-activity relationships among synthesized compounds. A novel series of indolo-quinazoline possessing benzene sulphonamides were synthesized for their potential anticancer activity. These results indicate that these compounds may constitute a new class of anticancer agents