Anupama Rani, Amit Kumar, Shubham Misra, Ram Sagar, Ritesh Raj, Rishi Sharma, Gyan Vardhan, Kahakashan Hussain, Pumanshi Rawat, Sangeeta Mohania, Leena Kaushik and Kameshwar Prasad
India
Posters & Accepted Abstracts: J Neurol Disord
Background & Purpose: Ischemic stroke (IS) is a complex and devastating vascular disease that has become one of the leading causes of disability and mortality worldwide. Various studies have shown the association between matrix metalloproteinase (MMP) family gene polymorphisms and IS. However, the results have been inconclusive. Objective: The present meta-analysis aimed to provide a comprehensive account of the association between MMP-3 5A/6A gene polymorphism and susceptibility to IS. Methods: A literature search for eligible genetic studies published before March 31, 2016 was conducted in the PubMed, Medline, EMBASE, OVID, and Google Scholar databases. The following combinations of main keywords were used: (�Matrix Mettaloproteinase-3 OR �MMP-3�) and (�genetic polymorphism� OR �single nucleotide polymorphism�) and (�ischemic stroke� OR �cerebral infarction� OR �IS�). Fixed or random effects models were used to estimate the Pooled Odds ratio (OR) and 95% confidence interval (CI). Statistical analysis was carried out by using STATA version 13.0 software. Results: Total 11 studies were included in our meta-analysis. No significant association was observed between MMP-3 5A/6A gene polymorphism [OR=0.91, 95% CI: 0.65�1.16] and risk of IS. Conclusion: Our meta-analysis shows that MMP-3 5A/6A gene polymorphism is not significantly associated with the risk of IS. Further prospective large epidemiological studies are needed to confirm these findings in different ethnicities.
Email: anupama21rani@gmail.com
Neurological Disorders received 1343 citations as per Google Scholar report
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