Association of immunomodulating risk factors with the impairment of anti-HBs development

JOINT EVENT ON 15^th International PHARMACEUTICAL MICROBIOLOGY AND BIOTECHNOLOGY CONFERENCE & 10^th Annual MEDICAL MICROBIOLOGY SUMMIT & EXPO

June 21-23, 2017 London, UK

Modhusudon Shaha and Sabita Rezwana Rahman

National Institute of Biotechnology, Bangladesh
University of Dhaka, Bangladesh

Posters & Accepted Abstracts: J Med Microb Diagn

Abstract :

Hepatitis B infection is one of the major causes of liver dysfunction and hepatocellular carcinoma in the world. Although a safe and effective vaccine is available since more than 30 years, the disease is still prevailing globally, especially in developing countries like Bangladesh. Non-responsiveness (<10 IU/ml) to hepatitis B vaccine is a common phenomenon even after complete vaccination, but the reason behind this is still unknown. In this study, we investigated whether several immunomodulating risk factors such as age, gender, cigarette smoking and diabetes have an effect on the impairment of anti-HBs development among vaccinated health-care workers through a cross-sectional study. Among the cigarette smokers, production of anti-HBs was found significantly less (POR 0.1129 [95% CI 0.03146�0.4052]; p=0.001) than the non-smokers after complete hepatitis B vaccination. However, the association of age, gender, and diabetes with the development of anti-HBs was not significant. The above data suggest that the prevention of smoking may help in reduction of non-responders and recommend testing anti-HBs status among smokers after vaccination and administering a booster vaccination if the anti-HBs titer is below the protective level

Biography :

Email: msshaha146@gmail.com