Regina C�©lia Poli-Frederico
University of Northern Parana (UNOPAR), Londrina-PR, Brazil
Posters-Accepted Abstracts: J Mol Genet Med
Osteoarthritis (OA) is the most prevalent disease of the musculoskeletal system and it has an important genetic component. Despite several reports have shown the involvement of pro-inflammatory cytokine such as interleukin-1�² and TNF-�±, the role of interleukin-6 (IL-6) in osteoarthritis is still unclear. Thus, this study aimed to analyze the relationship between the single nucleotide polymorphism in the portion - 572 of the promoter region of the IL-6 gene with hip and knee OA in the elderly. 257 physically independent elderly were recruited (92 individuals with osteoarthritis and 165 individuals without osteoarthritis). Blood samples were collected from patients for the DNA fragments extraction and amplification by qPCR. The degree of joint damage was assessed by radiographic classification based on the criteria of Kellgren and Lawrence. The functional status was evaluated by Lequesne and WOMAC questionnaires. It was observed that individuals carrying the C allele have lower susceptibility to osteoarthritis (OR = 0.51, 95% CI: 0.32- 0.80, p = 0.004) and less radiological impairment for both hip (Fisher-Freeman-Halton test = 4.2 and p=0.04) and knee joints (Fisher-Freeman-Halton test = 4.7 and p=0.03). Regarding functional status, individuals carrying the C allele has a lower degree of functional impairment assessed by WOMAC (p = 0.04). Additionally, it was observed a marked reduction in IL-6 serum levels in individuals with GC and CC genotypes when compared to individuals harboring GG genotype. In conclusion, the polymorphism -572G/C IL-6 is a protective factor for the presence and severity of hip and knee osteoarthritis in the elderly.
Email: reginafrederico@yahoo.com.br
Molecular and Genetic Medicine received 3919 citations as per Google Scholar report
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