Association of VEGF gene as prognostic marker in subjects with oral submucous fibrosis (OSMF) of North Karnataka population

13^th Asia-Pacific Oncologists Annual Meeting

October 17-19, 2016 Kuala Lumpur, Malaysia

Devishree V Rai

SDM College of Dental Sciences and Hospital, India

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Oral cancer imposes a considerable problem worldwide being a highly lethal and disfiguring disease. According to the report of the World Health Organization, oral cancer is the sixth most common cancer worldwide and the most common intraoral subtype is squamous cell carcinoma. The formation or progression of oral cancer may be associated with a polymorphism of the vascular endothelial growth factor (VEGF) gene. OSCC was associated with significantly elevated serum VEGF concentration and higher level of serum VEGF also correlated with lymph node metastasis and clinical stage of OSCC. There have been association of VEGF-460C/T polymorphism in oral cancer, diabetic retinopathy, breast cancer, prostate cancer, but very few studies are known to validate the association of the VEGF gene with potentially premalignant conditions like oral submucous fibrosis. The most frequently seen polymorphism is BstUI (C to T) located at the -460th nucleotide upstream of the VEGF gene. With the malignant transformation rate of OSMF being 7-30%, VEGF gene -460C/T can become an important prognostic marker. The aim of our study was to assess the polymorphic nature of VEGF -460C/T gene in subjects with oral submucous fibrosis of North Karnataka population and analyze the comparison between the association of VEGF -460C/T polymorphism in patients with oral submucous fibrosis and healthy controls.

Biography :

Devishree V Rai has completed her BDS degree from A B Shetty Memorial Institute of Dental Sciences & Hospital and is presently pursuing her MDS degree from SDM College of Dental Sciences & Hospital. She has presented poster titled “Virtopsy” for the National Conference held in Lucknow. She has presented case report on “Acromegaly” in PG Convention held in Bangalore. She has presented case report on “Odontogenic Myxoma” in a National Conference held in Mangalore. She has also been awarded the research grant from Indian Council of Medical Research for her dissertation.

Email: devishreerai@gmail.com