Better outcome in primary gastro-intestinal lymphoma operated before chemo/radiotherapy: An observation in children

7^th Global Summit on Cancer Therapy

October 05-07, 2015 Dubai, UAE

Basant Kumar

Sanjay Gandhi Post Graduate Institute of Medical Sciences, India

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Primary tumors of the gastrointestinal (GI) tract are rare in children and represent less than 5% of all pediatric neoplasms. Non- Hodgkin�¢����s lymphoma (NHL) remains the most common type of primary extra nodal lymphomas of the GI tract (5 to 10% of all NHL) while abdomen is the most frequent onset site of non-endemic Burkitt�¢����s lymphoma. We present our experience with 7 cases of GI lymphoma needed emergency surgery for bowel obstruction/perforation during and before chemo-radiation. We retrospectively reviewed the record from Feb 2011 to March 2014 and all patients needed surgery for bowel obstruction/perforation was included in study. Patients were registered according to criteria developed by Dawson and colleagues. Surgical outcome and quality of life was compared among the patients operated before and during chemo-radiation. Duration of follow-up was 3 month post surgery. Four out of 7 patients were operated during chemo-radiation in which 2 patients were died in post-operative period because of tumor load, immunosupression, malnutrition and sepsis. Rest 2 patients continued chemo-radiation but quality of life was not appropriate because of malnutrition and recurrent neutropenia and one patient was lost in follow-up. Three out of 7 patients were operated before initiation of chemo-radiation. All patients tolerated chemo-radiation better than previous group and their quality of life was better. Quality of life of the patients of GI lymphoma is better in those patients who had resection of the mass prior to chemo-radiotherapy rather than those who are subjected to surgery during chemo-radiotherapy regimen. Probably it occurs because of better oral intake though a detailed study is needed to reach a definitive result.

Biography :

Email: drbasant189@gmail.com