Biodegradable drug delivery vehicles produced by controlled ring-opening polymerizations

International Conference and Exhibition on Polymer Chemistry

November 14-16, 2016 Atlanta, USA

Mthulisi Khuphe and Paul D Thornton

University of Leeds, UK

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Polymers are often employed as drug carriers to provide protection to encapsulated therapeutic molecules against premature metabolism and clearance in vivo. Proteolytic enzymes may be exploited to trigger the swelling and/or degradation of (poly)peptidecontaining carrier vehicles, while reduced environmental pH may be exploited to trigger the hydrolysis of ester linkages in (poly) ester-containing carrier vehicles, resulting in controlled payload release, on-demand. We report the creation of several biodegradable polymeric nanomaterials from N-carboxyanhydride ring-opening polymerization (NCA ROP) and O-carboxyanhydride ringopening polymerization (OCA ROP). A range of delivery vehicles, including nanoparticles, chemical hydrogels and vegetable oil-based organogels have been created that selectively release encapsulated payload molecules upon interaction with acidic environmental pH and/or enzymes that are over-expressed at particular disease sites.

Biography :

Email: cp11mk@leeds.ac.uk