Biphasic Si-Ca-P ceramic for regenerative medicine: Scaffold processing and biocompatibility

3^rd International Conference and Expo on Ceramics and Composite Materials

June 26-27, 2017 Madrid, Spain

De Aza P N, Ros-Tarraga P, Mazon P, Rodriguez M A and Meseguer-Olmo L

Universidad Miguel Hern�¡ndez, Spain
Universidad Cat�³lica San Antonio de Murcia, Spain
Instituto de Cer�¡mica y Vidrio, Spain

Scientific Tracks Abstracts: J Material Sci Eng

Abstract :

The present study refers to the preparation and biocompatibility characterization of a biphasic Si-Ca-P scaffolds to be used as matrices for bone regeneration or as-specific release vehicles. Ceramics are widely used for bone tissue engineering purposes and in this study, a Si-Ca-P biphasic porous scaffold, with nominal composition 28.39 wt% 7CaOP2O52SiO2-71.61wt% 5CaOP2O5SiO2 was produced using the polymer replication method of homogeneous mixtures of fine synthetic 7CaOP2O52SiO and 5CaOP2O5SiO2 powders. Polyurethane sponges were used as templates and impregnated with ceramic slurry at different ratios, and sintered at 1450�ºC during 2 hours with 5�ºC/min as heating and cooling rates. The characteristics of the Si-Ca-P porous scaffolds and respective powder used as starting material were investigated by using SEM, particle size distribution, XRD and Hg porosimetry techniques. It was possible to produce highly porous biphasic Si-Ca-P scaffolds presenting micro and macropores and pore interconnectivity. In addition, bioactivity was evaluated by examining in vitro apatite formation in simulated body fluid (SBF) for several periods of time. The experimental results demonstrated that, during soaking in SBF the porous surface of the ceramic became coated by HAlike layer after 6 hours. Also, in vivo biocompatibility was tested by implantation in NZ rabbits�´ tibia. All animals survived the 6 months study period without evidence of inflammation or infection at the implantation site and strong adhesion between bone and the scaffolds was observed. The first results of in vivo tests on NZ rabbits showed good biocompatibility and osteointegration of the porous scaffolds implants, with higher osteoconductive properties and earlier bioresorption.

Biography :

De Aza P N received her Doctoral degree in Chemistry-Ceramin in 1995. She did a Post-doctoral degree at the IRC in Biomaterials at the Queen Mary College, University of London (UK) working on in vitro and in vivo behavior of bioceramics. At this moment, she is the Chair of the Materials Science, Optic and Electronic Technology department, Professor of Materials Science and Metallurgical Engineering and Researcher at the Bioengineering Institute at the Miguel Hernandez de Elche University.

Email: piedad@umh.es