BK virus nephropathy in renal transplant recipient: A single centre experience

19^th Global Nephrologists Annual Meeting

May 14-15, 2018 | Rome, Italy

Ghulam Farid Rana

Sheffield Kidney Institute-Sheffield Teaching Hispitals NHS Foundation Trust, UK

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Introduction: Reactivation of BK virus in the transplant kidney can lead to BK virus nephropathy (BKVN) in upto 10% of kidney transplant recipients. This is a single centre study looking at BK virus nephropathy rate and appropriateness of current screening and management approach. Methods: Retrospective analyses of 185 consecutive renal transplant recipients in a single centre, 2010-2012. Data Source: prospectively managed electronic patient record. Exclusions: any of death, graft failure or transfer in the first year. BKVN, BK viruria and BK viraemia rates were assessed. Results: 185 patients (69% male, 31% female) with mean age of 49 years +/- 4.3. 32 (17%) patients had BK viruria out of which 12 (6.5%) patients developed BK viraemia. There were two (1.1%) cases of biopsy proven BKVN leading to graft loss in one (0.54%) patient at 12 months post transplant. 244 urine and 156 serum samples were tested for BK virus PCR with positivity rates of 12.7% and 7.69% respectively. 20 patients had their IS reduced, eight of which on the basis of BK viruria. Discussion: Prevalence of BKVN at 12-month post transplant (1.1%) was similar to published prevalence of 0.85-6.4%. However, in-consistencies were identified vis-� -vis use of single diagnostic method, screening protocol and decision making around IS reduction. Based on these findings, we have developed comprehensive guidelines to adopt a uniform approach for screening and management of BK virus re-activation in renal transplant recipients and to treat BK virus reactivation before it causes irreversible graft damage. farid.rana@gmail.com