Breast cancer and obesity: The role of l-Carninine in prediction of answer to treatment and outcome of tumor in patients with obesity (Review of literature)

Joint Event on 4^th Annual Conference on Preventive Oncology & 4^th Annual Conference on Gynecologic Oncology, Reproductive Disorders Maternal-Fetal Medicine & Obstetrics

July 18-19, 2018 | Atlanta, USA

Hojouj Mohammad I M, I N Bondarenko, Hojouj T V and Tereshchinko P V

Dnipropetrovsk Medical Academy of Health Ministry of Ukraine, Ukraine

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Increasing the effectiveness of antitumor therapy in breast cancer patients who take L-carnitine during preoperative systemic antitumor therapy compared with patients receiving standard neoadjuvant systemic antitumor therapy served as a prerequisite for studying possible antitumor mechanisms of L-carnitine. The positive effect of L-carnitine is due to the transfer of palmn- fatty acid through the inner membrane into the mitochondrial matrix, which contributes to the formation of a significant number of ATP molecules. It has also been shown that L-carnitine can have a double protective effect, enhancing the energy dynamics of the cell and inhibiting the hyperexcitability of the cell membrane, making it an ideal tool for the prevention and treatment of complications of antitumor therapy and concomitant metabolic disorders. This work summarizes the results of epidemiological and clinical studies on the use of L-carnitine in the treatment of breast cancer.

Biography :

Hojouj Mohammad I M is an Associate Professor of State Establishment Dnipropetrovsk Medical Academy of Health Ministry of Ukraine Department of Oncology and Radiology, Master of Science in medicine. He completed his Master’s Degree and performed thesis “Effect of hematologic complications effectiveness of chemotherapy for metastatic breast cancer” from 01.09.2012 to 31.08.2014. He has been working as doctor-oncologist of the department of oncology and medical radiology since 15.09.2014. He performed scientific-research and clinical work, educational process in Internal Medicine and Medical Oncology. He has completely fulfilled the individual program of lecturer in oncology based on the standard program of the Ministry of Health of Ukraine and approved by the Academic Council and Rector of SE Dnipropetrovsk Medical Academy of Health Ministry of Ukraine.

E-mail: hojouj@yahoo.com