Breast cancer: Correlation of ultrasonographic features with molecular subtype

7^th World Congress on Breast Cancer

May 10-11, 2018 | Frankfurt, Germany

Ines Vieites Branco, Luciana Barbosa, Lara Batista, Anabela Ferrao, Conceicao Leal, Ana Teresa Aguiar and Antonio Guimaraes

Centro Hospitalar Vila Nova de Gaia, Espinho, Portugal
Instituto Portugues de Oncologia do Porto, Portugal

Scientific Tracks Abstracts: J Cancer Sci Ther

Abstract :

Aims & Objectives: The purpose of this study is to correlate the ultrasonographic features of previously diagnosed malignant breast cancers with their hormone receptor expression. Methods & Materials: The malignant breast nodules diagnosed by ultrasonographic-guided core biopsy, at our regional oncologic center, from July to December 2016 (n=172), had their ultrasound features retrospectively reviewed according to the breast imaging- reporting and data system (BI-RADS) lexicon. For each case the molecular subtype was obtained, consisting of positivity/negativity for hormone receptors (HR) and human epidermal growth factor receptor 2 (HER2), and correlated to the ultrasonographic characteristics. The statistical analysis was conducted using the software Statistical Package for Social Science (SPSS) v24, and a descriptive analysis using percentages was carried out, applying chi-square test for categorical data. A significance level of p<0.05 was used to determine significance. Results: HER2 and HR positive lesions showed more frequently an irregular morphology (78.6%, p=0.002) and non-parallel orientation (78.6%, p=0.033). HER2 positive and HR negative lesions presented more commonly an irregular morphology (94.4%, p=0.000), non-parallel orientation (88.9%, p=0.01) and lobulated margins (61.1%, p=0.016). HER2 negative and HR positive lesions had more often an irregular morphology (85.4%, p=0.000), non-parallel orientation (88.8%, p=0.000), lobulated margins (49.4%, p=0.000) and posterior attenuation (65.2%, p=0.004). HER2 and HR negative (triple negative) lesions showed mainly an irregular morphology (94.1%, p=0.000), non-parallel orientation (88.2%, p=0.002), lobulated margins (58.8%, p=0.028), and heterogeneous echotexture (82.4%, p=0.008). Conclusion: Knowledge of distinctive ultrasonographic phenotypes according to molecular subtypes could be important for earlier diagnosis and treatment, and ultimately improve outcomes.

Biography :

Inês Vieites Branco is currently a third year Radiology Resident at Centro Hospitalar Vila Nova de Gaia-Espinho, Portugal, and has completed her Master’s degree in Medicine from Instituto de Ciências Biomédicas de Abel Salazar- Porto, Portugal.
Email:inesbranco15@hotmail.com