Case report of an annular giant cell granuloma

20^th World Dermatology Congress

March 13-14, 2019 Singapore

Entela Shkodrani, Amarda Cenko, Genta Hylviu, Alert Xhaja and Barbara Shkodrani

University Medical Center of Tirana "Mother Teresa", Albania
Sapienza Universita di Roma, Ital

Posters & Accepted Abstracts: J Dermatol Dis

Abstract :

Annular Elastolytic Giant Cell Granuloma (AEGCG) is a rare granulomatous skin disease of undetermined cause, characterized by annular plaques with raised erythematous borders. The lesions are localized mainly in the sun exposed are of the skin. Pathogenesis of AEGCG is poorly understood. Initially described as actinic granuloma, atypical necrobiosis lipoidica and Miescherâ??s granuloma of the face, it is proposed that ultraviolet radiation-induced cellular immunological reaction wherein the elastin fibers immuno-pathogenicity plays a central role resulting in the formation of the elastocytic granuloma with ultimate destruction of elastin fibers. Histopathologically, it is characterized by elastin degeneration, multinucleate giant cells and elastophagocytosis. A higher incidence of diabetes mellitus has been reported with AEGCG. We report a case of a 56-years old female, diagnosed with AEGCG at the Dermatology Department of University Hospital Center of Tirana. The patient was diabetic for more than one decade. On the examination she presented well-defined skin colored to erythematous annular, well defined and arciform lesions at the face and also on the exposed areas of the neck, arms and legs. Mucosae, palms, soles, scalp, hair and nails revealed no abnormality. Skin biopsy revealed presence of epithelioid cells with many multinucleated giant cells and foreign body type with a presence of mild perivascular lymphoid infiltrate. Complete resolution was seen in two months, after starting Hydroxychloroquine 200 mg twice a day.

Biography :

Entela Shkodrani is the Dermatologist, Associated Professor at Department of Dermatology and Venereology, UHC “Mother Theresa’, Tirana, Albania. Graduated as Medical Doctor in 1992, at the Faculty of Medicine, University of Tirana. Three years of training 1995-1998 in Dermatology and Venerology, at the Clinic of Dermatology, University Hospital Center of Tirana. Master Degree in 1998 with the thesis “Atopic Dermatitis in Children, ISSAC study in Tirana”, post University School of the Faculty of Medicine, University of Tirana. In 2015 graduated as Associate Professor in Medicine, University of Medicine, Tirana. Member and General Secretary of the Albanian Association of Dermatology and Venereology. Member of EADV, European Academy of Dermatology and Venereology Member of ISD, International Society of Dermatoscopy.

E-mail: entela.shkodrani@gmail.com