Cassia occidentalis: Effect on skin wound healing in mice induced by Bootrops moojeni venom

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

Leila Maria Leal Parente

Accepted Abstracts: Pharmaceut Reg Affairs

Abstract :

The Bothrops is found in the Americas and are responsible for most snake bites in Brazil. In bite site can occur presence of edema, bruising, redness and hemorrhagic blisters that can progress to necrosis, which affects skin, muscles and tendons. Studies have been developed to minimize local effects caused by Bothrops poisoning, such as use of various substances and therapies, and among them, use of medicinal plants such as Cassia occidentalis (C. occidentalis) commonly used for snakebite. This study was aimed at investigating to evaluate healing activity of ethanol extracts of root and leaves of C. occidentalis in skin wounds in mice induced by the venom of Bothrops moojeni. Extracts were produced by percolation and incorporated into Lanette 10% cream. Cream obtained was administered in skin wounds by seven and fourteen days. Histological evaluations were assessed in these two periods. It was found that extract from leaves of C. occidentalis stimulated angiogenesis and reduced epidermal hyperplasia, acting positively on healing process and minimizing local effects caused by poisonous accident.

Biography :

Veterinary Medicine, Federal University of Viçosa (1990). She specializes in Science, Federal University of Goiás (UFG) (2000). Master's in Biology, concentration area Animal Physiology by UFG (2004). PhD in Animal Science, concentration area Pathology and Surgery by UFG (2008). She has experience in veterinary medicine, with emphasis on Veterinary Clinic and Complementary Veterinary Medicine. She specializes in Herbal Medicine, Faculty of Pharmacy, UFG (2010). It is scholarship of Scientific and Technological Development Fund (2010-2013), which conducts research to evaluate healing wound activity and ticks control with medicinal plants. She is related to OMICS Groups and Brazilian Animal Science.