CD34+/CD45- stem cells from diverse lineages and their applicability for cell therapy

5^th International Conference on Tissue Engineering & Regenerative Medicine

September 12-14, 2016 Berlin, Germany

Bipasha Bose

Yenepoya University, India

Scientific Tracks Abstracts: J Tissue Sci Eng

Abstract :

From the perspective of cell therapy and understanding the basic biology of adult stem cells residing in tissues of the different germline origin, we have isolated and characterized CD34+/CD45- stem cells from various organs, other than bone marrow. These studies were aimed at establishing a proof of concept for the translational applicability of such cells in preclinical animal model system. Till now, in clinical scenario, bone marrow has been the exclusive source for CD34+/CD45- for all the therapeutic applications. The advantage of using other cell types for obtaining CD34+/CD45- is avoiding the invasive bone marrow collection procedure. The presence of CD34+/CD45- cells in liver (endoderm), skin (ectoderm) and muscle (mesoderm) were established using immunofluorescence staining. The CD34+/CD45- were isolated from liver, muscle and skin using FACS sorting. Also, CD34+/CD45- cells from muscle had proven to ameliorate muscular dystrophy in mouse model of muscular dystrophy.

Biography :

Bipasha Bose holds a PhD degree in Cancer Biology from Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India since 2004. She has about 12 years of Post-PhD Research Experience working in Stem Cell Biology, in academia and industry in India, Belgium and Singapore. She holds key skills in the field of clinical, as well as, R&D grade stem cells. She has several international publications and two patents to her credit. Her present focus is basic biology of adult CD34+/45- stem cells and also various aspects of ocular stem cells and cancer stem cells.

Email: bipasha.bose@gmail.com