Changes in some blood serum enzymes after the use of glucocorticoids

6^th Global Veterinary Summit

November 14-16, 2016 Atlanta, USA

JevgenijaKondratjeva, AijaIlgaza

Latvia University of Agriculture, Latvia

Posters & Accepted Abstracts: J Vet Sci Technol

Abstract :

Glucocorticoids are widely used in human and veterinary medicine. They are indicated in diseases associated with inflammation, pruritus and others. Except the positive effect of this group of drugs, there are complications associated with the use of steroids, such as diabetus mellitus, iatrogenic Cushing syndrome, steroidhepatopathy in dogs. Steroid hepatopathy is unique pathology in dogs which may develop even after the first use of glucocorticoids. Despite this fact usually the steroid hepatopathy is taken as mild secondary complication in dogs. To describe the influence of drugs to the body, studies should be made on clinically healthy animals for better understanding of the effect.But sometimes animals with discovered pathologies may react to medication differently. The objective of this study is to compare the changes in some blood serum enzymes in healthy dogs and in dogs with already discovered immunmediated pathologies after the long-lasting methylprednisolone acetate was used once. Seven clinically healthy beagle dogs and seven home dogs took part in the study. The study took place with the permission N 70 of Latvia Comittee of Ethics.To reach the aim such blood serum enzymes as ALAT (alaninaminotransferase), AP (alkaline phosphatise) and cAP (corticosteroid induced alkaline phosphatase) were analysed and changes were compared. There was significant difference inALAT concentration between clinically healthy and injured dogs. AP and cAP concentration were within the reference ranges on the 29th day in both groups after the glucocorticoid was used once.

Biography :

Email: jkondratjeva@inbox.lv