Changes in the gabaergic sugnalling in the prefrontal cortex of mice model of posttramautic stress disorder

Joint Event on 31^st Euro Congress on Psychiatrists and Psychologists & 25^th International Conference on Neurology & Neurophysiology

April 05-06, 2021 | Webinar

Arina Serbina, Alexander Bogdanov and Yuriy Pankratov

Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
The University of Warwick, United Kingdom

Scientific Tracks Abstracts: J Neurol Disord

Abstract :

Ithasbeensuggestedthattheneuronsofprefrontalcortex,alongwiththehippocampusandamygdala, can undergoes morphological and molecular remodelling during the development of stressrelated disorders, such as PTSD[1]. Pathological remodeling of the GABAergic inhibitory signalling during stress disorders might bring significant contribution to impairment of synaptic plasticity [2] and cognition [3]. In this work we have used an experimental model of PTSD in mice, based on a single prolonged stress protocol [4] and studied alterations in the synaptic transmission and longterm synaptic plasticity in the pyramidal neurons of prefrontal cortex.The stress state in the animals was evaluated with the aid of Open field and Elevated cross-maze behavioural tests. We have found an increase in the quantal amplitude of GABA-ergic spontenous inhibitory synaptic currents (mIPSCs) in the neurons of prefrontal cortex of stressed animals. There were also elevation inthefrequencyofmIPSCinneuronsofthestress-groupvscontrolgroup.Theseresultsdemonstrate that that exposure to stress can cause an up-regulation of the GABAergic inhibitory system in the prefrontal cortex. In the experiments on long-term potatiation (LTP) of field postsynaptic potentials (fEPSP), we have observed that the amplitude of LTP induced by the theta-burst stimulation in the prefrontal cortex synapses of stressed mice was much lower than in the control group. The data obtained suggest that stress-induced up-regulation of inhibitory signalling can affect long-term synaptic plasticity in the prefrontal cortex and thereby contribute to congnitiveimpairment.

Biography :

Arina Serbina is a 5th year graduate student, School of Life Sciences, Immanuel Kant Baltic Federal University, specialty bioengeneering and bioinformatics; Alexander Bogdanov is a researcher at School of Life Sciences, Immanuel Kant Baltic Federal University (Russia, Kaliningrad). Dr.Yuriy Pankratov - PhD, Associate professor at School of Life Sciences at the University of Warwick, UK.