Chirality and diastereoselectivity of four coordinated non-planar metal(II)-complexes induced by chiral N O-chelate ligands

18^th International Conference on Pure and Applied Chemistry

August 31- September 01, 2018 | Toronto, Canada

Mohammed Enamullah

York University, Canada

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

Four coordinated non-planar and C2-symmetrical metal(II)-complexes with tetrahedral to distorted square-planar geometry exhibit chirality-at-metal center induced by chiral N^O-chelate ligands. The chirality of the whole coordination unit is designated by Î? (right) - and Î? (left)-handed descriptors. The chirality and diastereoselection of R or S-N^O-chelate ligands on coordination with the metal(II) ions will lead to the formation of opposite Î?- or Î?-configuration at-metal center and provide two diastereomers, Î?-M(R-N^O)2 and Î?-M(R-N^O)2 {or Î?-M(S-N^O)2 and Î?-M(S-N^O)2}. While the racemic ligands (R/S-N^O) provide a mixture of all four diastereomers (Scheme 1). Intra molecular non-covalent interactions that shows within the metal-chiral chelate unit lead to a free-energy divergence between the two diastereomers (Î? vs. Î?), thereby one of the diastereomers is thermodynamically preferred, Î?-M(R-N^O)2 {or Î?-M(S-N^O)2 } [1-5].

Biography :

E-mail: enamullah@juniv