Helena Serra Azul Monteiro
Federal University of Ceara, Brazil
Posters & Accepted Abstracts: J Nephrol Ther
Natriuretic Peptides (NPs) have significant interest in regulating cardiovascular, renal and endocrine homeostasis and have been described in the snake venoms. Crotalus durissus cascavella, a characteristic terrestrial snake of caatinga biome of northeastern Brazil, has in his whole venom an NP (NPCasca) of which are reported vascular and renal effects. The aim of this study was qualitative comparisons of the results obtained on isolated rat kidney perfusion system of the isolated and the synthetic peptides from Crotalus durissus cascavella venom (NPCasca and NPCdc, respectively) in different concentrations. The effects of NPCdc were investigated in four concentrations (0.03 �¼g/mL, 0.1 �¼g/mL, 0.3 �¼g/mL and 1 �¼g/mL) and compared to the effects of NPCasca in two concentrations (0.1 �¼g/mL and 0.3 �¼g/mL). There was increase in perfusion pressure (PP) in 0.03 �¼g/mL and reduction in 1 �¼g/mL. Renal vascular resistance (RVR) was increased at 0.03 �¼g/mL. Urinary flow (UF) increased in 0.03 �¼g/mL and decreased in 0.1 �¼g/mL and 1 �¼g/ mL. The glomerular filtration rate (GFR) was reduced at all the concentrations tested. Percentage of the total and proximal tubular transport of sodium (%TNa+) and chloride (%TCl-) showed reductions at all concentrations tested. Percentage of the total proximal tubular transport and potassium (%TK+) were reduced in 0.03 �¼g/mL and 0.3 �¼g/mL. These results do not reproduce the actions of the original molecule: Increased FU, GFR and urinary sodium excretion, similar to the effects caused by most NPs. However, these same concentrations were unable to cause changes in RVR, contrary promoted reduced GFR, leading also to reduce UF at 0.1 �¼g/mL. Transports, nevertheless, were reduced.
Journal of Nephrology & Therapeutics received 784 citations as per Google Scholar report
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