GET THE APP

Computer aided screening of mangrove ecosystem derived compound against Acetyl-cholinesterase
..

Journal of Tissue Science and Engineering

ISSN: 2157-7552

Open Access

Computer aided screening of mangrove ecosystem derived compound against Acetyl-cholinesterase


Joint Event on 9th International Conference and Exhibition on Tissue Engineering and Biobanking & 9th International Conference and Exhibition on Tissue Science and Regenerative Medicine

April 23-24, 2018 Las Vegas, USA

Shahid Ullah

Huazhong University of Science and Technology, China

Scientific Tracks Abstracts: J Tissue Sci Eng

Abstract :

Alzheimer�s disease (AD) is considered as the most common type of dementia among older people. Almost 9 million people are suffering from AD in china and increasing with the course of time. Currently many different herbs are used for the treatment of AD including six Flavors Rehmannia Pills, Gastrodia and Uncaria Drink. It is been suggested that some Acetyl-cholinesterase inhibitors induced molecular and cellular change that directly influence AD pathogeneses. In our study literature search was perform to find Mangrove eco-system phytochemical structures by using Builder software implemented in Molecular operating environment (MOE 2009). Acetyl-cholinesterase (PDB ID 1EVE) structure with bound ligand was retrieved from protein data bank. Molecular docking was performed by triangular matcher placement method and rescore by London dG parameter. The crystal structure has bound ligand which was active against acetyl-cholinesterase. It can be concluded by docking analysis of different compounds that mangrove ecosystem compound may serve as good inhibitors against Acetyl-cholinesterase.

Biography :

Shahid ullah is from Shenzhen University, China.
Email:shahidullah@hust.edu.cn
 

Google Scholar citation report
Citations: 807

Journal of Tissue Science and Engineering received 807 citations as per Google Scholar report

Journal of Tissue Science and Engineering peer review process verified at publons

Indexed In

 
arrow_upward arrow_upward