Mislav Mustapic
University of Osijek, Croatia
Posters & Accepted Abstracts: Med chem
In this reserch we demonstrate that porous Fe3O4 structures can be used as a vehicle for the transport of drugs adsorbed onto their porous surface. We used methyl blue as a surrogate drug. It was adsorbed onto the Fe3O4 surface, and released into the surrounding water via application of a magnetic field. Controlled release of the methyl blue to water was then achieved by application of a magnetic field. Application of a pure AC field caused release of the methyl blue. However, a combination of both DC and AC fields resulted in much faster release. This study demonstrates a concept for controlled drug delivery, where pharmaceutical molecules, similar to methyl blue, would be adsorbed onto porous Fe3O4 structure and then released at a target by application of appropriately localised magnetic fields. Furthermore, we developed superparamagnetic nanoparticles for activation of the MscL nanovalves incorporated in liposome by magnetic field. Synthesised CoFe2O4 nanoparticles were labelled by -SH groups for attachment to MscL channels. Activation of MscL by magnetic field with the nanoparticles attached was examined by the patch clamp technique showing that the number of activated channels under ramp pressure increased upon application of the magnetic field. A combination of MscL channels and the magnetic nanoparticles generated for this study holds promise for use in the development of â??smart liposomesâ?, a new generation of liposome drug delivery system.
Email: mislav.mustapic@gmail.com
Medicinal Chemistry received 6627 citations as per Google Scholar report
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