COPD and its association with gene polymorphism and cigarette smoke

3^rd International Conference on Chronic Obstructive Pulmonary Disease

July 11-12, 2016 Brisbane, Australia

Balagopalan Unni, Tapan Dey, Kabita Gogoi, Jatin Kalita and Minakshi Bhattacharjee

CSIR- North East Institute of Science & Technology, India
Assam Down Town University, India

Posters & Accepted Abstracts: J Pulm Respir Med

Abstract :

Chronic Obstructive Pulmonary Disease (COPD) is considered to be one of the most common preventable diseases. Large number of population studies has cited the alpha-1 antitrypsin gene polymorphism is one of the primary genetic reasons for its pathogenesis. Among the environmental factors, along with C-F compounds, cigarette smoke is considered to be the main factor for the disease progression. But the question is how the cigarette smoke is related with gene polymorphism? Th e question is indeed a complex issue. We are trying to understand the issue, in terms of the cigarette smoke compounds, how they are regulating the antioxidant enzymes. We are getting some interesting results, how the cigarette smoke extracts aff ecting the glutathione S-transferase enzyme machinery. We are searching for the mechanism concerning the infl ammatory eff ect of the extracts. From the genetic point of view, the gene expression studies of the determinants of cellular GSH levels are also under progress. We have performed the experiments on gene polymorphism studies of COPD patients and have shown, the GSTM1 gene polymorphism is the main factor for the disease among the coal miners. Th e studies relating the understanding of the whole cigarette smoke metabolizing pathway is going on and will be presented and discussed.

Biography :

Email: bgunni@yahoo.com