Correlation of leptin with clinical and pathological features of breast cancer

Cancer Diagnostics Conference & Expo

June 13-15, 2016 Rome, Italy

Samuel Yaw Opoku

International Islamic University Malaysia, Malaysia

Posters & Accepted Abstracts: J Cancer Sci Ther

Abstract :

Introduction: Leptin hormone which is secreted from the adipose tissue and responsible for satiety through its action on leptin receptors was found to have some adverse effects on other tissues. It promotes the tumorigenesis of breast tissue. Objectives: The objective of the present study is to show the correlation between leptin and clinico-pathological features of breast cancer. Methodology: Serum leptin levels were measured in the control and study group. Immunohistochemistry for the leptin and its receptors expression were studied in the breast cancer tissue and the normal adjacent tissue. Results: Significant differences in serum leptin levels between the control and the study group were observed. No differences between the pre and post-operative serum leptin levels. Immunohistochemistry studies showed that leptin and its receptors were positively expressed in the majority of breast cancer tissue and this expression was significantly correlated with the distant metastasis of the breast cancer. Conclusion: Leptin may have an important print in mapping the clinico-pathological features of breast cancer. Attempts to inhibit leptin levels might help in the prevention of breast cancer and might lower its aggressiveness.

Biography :

Email: salshibli2004@yahoo.com