Cross talk of the first-line defense TLRs with PI3K/Akt pathway, in preconditioning therapeutic approach

8^th Euro Global Summit on Cancer Therapy

November 03-05, 2015 Valencia, Spain

Mohammad Baghi Yazdi

Shahid Sadoughi University of Medical Sciences, Iran

Posters-Accepted Abstracts: J Cancer Sci Ther

Abstract :

Toll-like receptor family (TLRs), pattern recognition receptors, is expressed not only on immune cells but also on non-immune cells, including cardio-myocytes, fibroblasts and vascular endothelial cells. One main function of TLRs in the non-immune system is to regulate apoptosis. TLRs are the central mediators in hepatic, pulmonary, brain and renal ischemic/reperfusion (I/R) injury. Up-regulation of TLRs and their ligation by either exogenous or endogenous danger signals play critical roles in ischemia/ reperfusionâ��induced tissue damage. Conventional TLR-NF-�ºB pathways are markedly activated in failing and ischemic myocardium. Recent studies have identified a cross talk between TLR activation and the PI3K/Akt pathway. The activation of TLRs is proposed to be the most potent preconditioning method after ischemia, to improve the cell survival via the mechanism involved the PI3K/Akt signaling pathway and to attenuate the subsequent TLR-NF-�ºB pathway stimulation. Thus, TLRs could be a great target in the new treatment approaches for myocardial I/R injury.

Biography :

Email: drbaghi7272@yahoo.com