Cur cumin has a dual effect on targeting the lung cancer cell lines

2^nd International Conference on Respiratory and Pulmonary Medicine

October 17-18, 2016 Chicago, USA

Amin Tashakor, Mahshid H-Dehkordi

Apoptosis Research Centre, National University of Ireland Galway

Posters & Accepted Abstracts: J Pulm Respir Med

Abstract :

Exposure to arsenic is one of the major causes of lung cancer due to production of Reactive Oxygen Species (ROS). Herbal medicine is a new approach used for prevention or treatment of cancers. Among various herbal compounds, a lot of attention has been paid to cur cumin, as antioxidant, anti-proliferative, anti-carcinogenic and anti-tumour and pro-apoptotic properties of cur cumin have been well studied. In the present study, we investigated the effects of cur cumin on lung cancer cell lines and arsenic-treated lung cancer cell lines, originated from different stages of lung cancer development. Here, we measured ROS generation and caspase 3/7 activity for both cur cumin-treated cell lines and those co-treated with arsenic and cur cumin. Then, we studied lipid peroxidation, intracellular ATP content, and cytochrome c release to further investigate how ROS generation and cur cumin exert synergistic effects and direct cells toward apoptosis. According to our data, cur cumin has a dual effect on ROS generation which is dependent on specific concentration as a threshold and seems to induce apoptosis by two different mechanisms. Moreover, for the first time we report that cur cumin delays the drop in ATP levels in these cell lines and hence provides required energy for apoptosis process. Furthermore, western blot analysis reveals that release of cytochrome c is highest when ATP begins to drop in the presence of cur cumin. To sum it up, it seems that curcumin is strong candidate for prevention or treatment of lung cancer, especially at stage 2.

Biography :

Email: amintashakor@ymail.com