CURCUMIN ADMINISTRATION ACCELERATES WOUND REPAIR AND REGENERATION IN THE EXCISION WOUND OF MICE EXPOSED TO DIFFERENT DOSES OF FRACTIONATED γ-RADIATION

Global Wound Care Congress

September 12-13, 2016 San Antonio, USA

Ganesh Chandra Jagetia and Golgod Krishnamurthy Rajanikant

Mizoram University, India
National Institute of Technology, India

Posters & Accepted Abstracts: J Nurs Care

Abstract :

Ionizing radiations used to treat cancer in more than 50% cases and fractioned irradiation before or after surgery of malignant tumors leads into a high frequency of wound healing related complications indicating the need to devise strategies that can reduce these complications. Curcumin or diferuloylmethane is an active principle present in the turmeric, which gives a characteristic flavor and yellow color to different cuisines. It has been credited with several medicinal properties in India and Asia. Therefore, we decided to study its wound healing activity in the deep excision wound of mice exposed to different doses of fractionated �³-irradiation by mimicking clinical conditions. A full-thickness dermal excision wound was created on the shaved dorsum of mice orally administered or not with 100 mg/kg body weight of curcumin before partial body exposure to 10, 20 or 40 Gy given as 2 Gy/day for 5, 10 or 20 days. The wound contraction was periodically studied by capturing video images of the wound from day one until complete healing of wounds. Fractionated irradiation of mice caused a dose dependent delay in the wound contraction and prolonged wound healing time, whereas curcumin administration prior to fractionated irradiation resulted in a significant rise in the wound contraction and curtailed mean wound healing time. Fractionated irradiation reduced the synthesis of collagen, DNA and nitric oxide in the regenerating wounds at different post-irradiation times, whereas treatment of mice with curcumin before irradiation elevated the synthesis of collagen, DNA and nitric oxide significantly. Histological examination revealed a reduction in the collagen deposition, fibroblast and vascular densities after fractionated irradiation, whereas curcumin pretreatment inhibited this decline significantly. Our study demonstrates that curcumin pretreatment accelerated healing of irradiated wound and could be a substantial therapeutic strategy in the management of irradiated wounds.

Biography :

Email: gc.jagetia@gmail.com