Cytokine storm in tuberculosis and IL-6 involvement

4^th World Congress on Advancements in Tuberculosis and Lung Diseases

April 25, 2022 | Webinar

Funmilayo Grace Boni

Southwest University, China

Scientific Tracks Abstracts: Clin Respir Dis Care

Abstract :

Statement of the Problem: Tuberculosis is probably the most seasoned illness of the humanity. Intricacies or subsequent death emerging from these infections are frequently connected with cytokine storm. Interleukin-6 (IL-6) plays a crucial role in the immune response to tuberculosis. Therefore, there is a need to research some new therapeutic approaches to block IL-6 signaling that are right now being applied to the M. tuberculosis. In this review, we investigate the implication of IL-6 in the context of tuberculosis research. Methodology & Theoretical Orientation: Summary of studies demonstrating the implication of IL-6 in the inflammation. The recapitulation of the repurposing of anti-IL-6 therapeutics for TB. Findings: in this studyï¼?Cytokine storm in tuberculosis can be targeted via the JAK/STAT pathways. Therapeutic avenues dampening IL-6 can quell the storm. Conclusion & Significance: An understanding of monocyte- and macrophage-mediated IL-6 release as part of the “cytokine storm” has played a role in a greater understanding of TB. IL-6 was identified as a major driver of disease severity in TB. TB patients should therefore be treated with anti-IL-6 therapeutics, as blunting IL-6 production may be advantageous in attenuating “cytokine storm” from TB. Researches on TB, are making tocilizumab and other anti IL-6 therapeutic approaches available to TB patients, who are believed to face an elevated mortality from complications of M. tuberculosis.

Biography :

Dr. Funmilayo Grâce Boni is currently a third year PhD student in Biochemistry and Molecular Biology at Southwest University. Her thesis title is: Isolation and characterization of ethambutol resistant from transposon insertion library of M. tuberculosis. Her research is focused on ethambutol drug resistance. She is particularly interested in cytokine, drug resistance, and diagnosis and treatment of tuberculosis. She has spoken at a number of conference and has published book reviews.