Cytotoxic activity of acyl phloroglucinols isolated from the juvenile leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt

3^rd World Congress on Cancer Science & Therapy

October 21-23, 2013 DoubleTree by Hilton Hotel San Francisco Airport, CA, USA

Maha M. Salama, Fathy M. Soliman, Magda M. Fathy, Ali M. El-Halawany and Fatema R. Saber

Posters: J Cancer Sci Ther

Abstract :

Aworldwide increasing interest is continuously directed towards searching for cheap tumour inhibitors or cytotoxic compounds from plant origin that might help in chemotherapy and /or chemoprevention of different types of cancer. Eucalyptus cinerea F. Muell. ex Benth. (Silver Dollar Gum, Argyle Apple and Mealy Stingybark) belongs to the family Myrtaceae .Two acyl phloroglucinol compounds namely; Sideroxylonal B (CM 1 ) and macrocarpal A (CM 2 ) were isolated from the Chloroform: Methanol extract (80:20) of the juvenile leaves of Eucalyptus cinerea F. Muell. ex Benth. cultivated in Egypt. Identification of the isolated compounds was established on the basis of physico-chemical properties and 1D and 2D NMR spectroscopy. The two compounds are isolated for the first time from this species.The isolated compounds were tested against three human cancer cell lines; HEP2, CAco and MCF7. Both CM 1 and CM 2 compounds showed moderate to potent cytotoxic activity against the three tested human cancer cell lines with IC 50 7.2, 4, 4.4 and 14.8, 11.4 and 7.8 μg/ml against HEP2, CAco and MCF7 respectively. Results evidenced that CM1 was more potent than CM 2 as a cytotoxic agent against two of the tested cell lines CAco and MCF7 (IC 50 = 4 & 4.4 μg/ml, respectively). Keywords: Eucalyptus cinerea F. Muell. ex Benth, cytotoxic acyl phloroglucinol, Sideroxylonal B and macrocarpal A.