Cytotoxic activity of crude extract from Sargassum polycystum and selected Philippine seaweeds against A549 human lung adenocarcinoma cell line

International Conference and Exhibition on Marine Drugs and Natural Products

July 25-27, 2016 Melbourne, Australia

Krisel Rosales-Sandoval

Philippines University, Philippines

Posters & Accepted Abstracts: J Pharmacogn Nat Prod

Abstract :

Cancer is one of the most dreaded diseases worldwide with limited treatment and management strategies often accompanied by serious side effects. Previous studies on marine products particularly seaweeds pose a significant avenue for alternative cancer treatment. This study determined the cytotoxic activity of selected Philippine seaweeds namely Caulerpa lentillifera (CLDE), Eucheuma denticulatum (EDDE), Kappaphycus alvarezii (KADE) and Sargassum polycystum (SPDE). Dichloromethane crude seaweed extracts were tested against A549 human lung adenocarcinoma cell line using 3-(4, 5-dimethylethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assay. Results indicate that SPDE exerts the highest cytotoxic activity against the cancer cell line with IC50 of 6.00�±0.19�¼g/mL as compared to other seaweeds tested (CLDE=49.39�±0.61�¼g/mL; EDDE=>50�¼g/mL; KADE=45.44�±4.51�¼g/mL). Phytosterol is the common phytochemical among the seaweed extracts tested using standard phytochemical analysis and Fourier Transform Infrared Spectroscopy (FTIR). SPDE shows potential for the treatment of lung adenocarcinoma and warrants further studies for the isolation of its bioactive compounds.

Biography :

Email: kriselrsandoval@gmail.com