Designing the best nanoparticles for drug delivery to tumors: Optimizing nanoparticle properties

International Conference and Exhibition on Biosensors & Bioelectronics

May 14-16, 2012 Embassy Suites Las Vegas, USA

Kristin Yaehne

Scientific Tracks Abstracts: J Biosens Bioelectron

Abstract :

Nanoparticles are increasingly used in medical applications such as drug delivery, imaging and biodiagnostics, particularly for cancer. The design of nanoparticles for tumor delivery has been largely empirical, owing to a lack of quantitative data on angiogenic tissue sequestration. Using fluorescence correlation spectroscopy we have determined the uptake rates of nanoparticles into angiogenic blood vessel tissue. We show that uptake is dependent on surface charge. Moreover, the size dependency strongly suggests that nanoparticles are taken up by a passive mechanism that depends largely on geometry.