Development, characterization and biological evaluation of novel glass-like coatings for cardiovascular implant application

2^nd International Conference and Expo on Ceramics & Composite Materials

July 25-26, 2016 Berlin, Germany

M Amlung, K Kiefer, O C Aktas, P W de Oliveira and H Abdul-Khaliq

INM � Leibniz-Institute for New Materials, Germany
Saarland University, Germany

Scientific Tracks Abstracts: J Material Sci Eng

Abstract :

Introduction: Glass-like coatings are used due to their excellent properties in a broad application field like drug delivery systems or as implant coating for bone repair. However these glass-like coatings can only be generated at relatively high temperatures that limit their application in temperature-sensitive areas. Therefore, new developments and further research is going on to provide useful coatings also in these fields, e.g., as coating for cardiovascular implants. Methods: Two glass-like coatings have been developed and characterized. These coatings have been applied using the wellknown sol-gel-technique and tempered at moderate temperatures in different atmospheres. Afterwards the biocompatibility using human umbilical vein endothelial cells (HUVEC) has been investigated. Results: The developed glass-like coatings possess excellent optical, chemical, and biological properties. By altering the existing sintering atmosphere, the cellular growth could be selectively influenced in a positive and a negative way. Additionally the coatings have been proven to be of radiolucent nature that makes them attractive for different fields. Conclusion: The developed glass-like coatings are promising coatings for a later cardiovascular application. A later usage as closing layer on thin, fine, and sensitive wires like stents is cogitable. First and foremost these coatings can contribute in a better acceptance of an implant in the human body.

Biography :

M Amlung has completed his PhD in 1998 in Chemistry at Saarland University and has been working since 1996 at INM – Leibniz-Institute for New Materials in Saarbruecken as Scientific Officer.

Email: martin.amlung@leibniz-inm.de