Development of a novel antimicrobial essential oil based natural hydrogel wound dressing

International Conference on Polymer Science & Engineering

August 22-24, 2016 New Orleans, USA

Chuysinuan P, Chimnoi N, Makarasen A, Reuk-ngam N, Supaphol P and Techasakul S

Chulabhorn Research Institute, Thailand
Chulalongkorn University, Thailand

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Wound dressing can be developed from traditional passive materials that focused on moisture management and active ingredients delivery in the local wound environment. In this work, new biomaterial wound dressings was developed based on gelatin containing herbal substances (essential oil), a substance from the plant Eupatorium adenophorum Spreng (Crofton weed) that used as traditional wound healers. The E. adenophorum essential oil was first identified the chemical composition by using GC-MS analysis. The principal components of the oil were p-cymene (16.23%), bornyl acetate (11.84%), amorpha-4, 7(11)-diene (10.51%). The hydrogel wound dressing containing essential oil was then characterized for their antibacterial activity against Gram-positive and Gram-negative in order to elucidate their potential for use as antibacterial wound dressings by using agar disk diffusion methods. The result showed that E. adenophorum essential oil and the essential oilloaded gelatin hydrogel inhibited the growth of the test pathogens, Staphylococcus aureus and Staphylococcus epidermidis and increased with increasing the initial amount of essential oil in the hydrogels which confirmed their application as antibacterial wound dressings. The physical properties such as gel fraction, swelling and weight loss behavior, water vapor transmission rate (WVTR), release characteristics and tensile strength were investigated to evaluate the usefulness of hydrogel to wound dressing. Furthermore, the potential use of these wound dressings was further assessed in terms of the indirect cytotoxicity, in vitro attachment and proliferation of dermal human fibroblasts cultured in the hydrogel wound dressings.

Biography :

Email: piyachat@cri.or.th