Development of a novel nano-biomaterial by dispersion of zero valent iron nanoparticles

4^th World Congress on Cancer Science & Therapy

October 20-22, 2014 DoubleTree by Hilton Hotel Chicago-North Shore Conference Center, USA

Selcan Karakuş, Tuba Şişmanoglu, Ayşen Kolan and Ayben Kilislioglu

Accepted Abstracts: J Cancer Sci Ther

Abstract :

The importance of studies on developing new materials with improved properties; such as anti bacterial activity, biocompatibility and anticancer properties are increasing gradually every day. Stronger mechanical properties can be obtained by adding a small amount of inorganic nanofiller into the organic matrix. Homogeneous nanodispersion of inorganic phase in nanodimension into the organic matrix is very important in developing new biomaterials with advanced features. In this study a natural biodegradable and nontoxic biopolymer and natural inorganic nano filler are used to develop a new nanobiomaterial with antibacterial activity. In order to obtain unique properties and impact we should understand and control the structure at the molecular level. One of the most important factors here is to achieve the nano dispersion of zero valent metal in the biopolymer matrix. The objective of this study is preparation of zero valent iron nanoparticles by chemical methods and then mixing sub-components in nanoscale to create unique antibacterial property. When exposed to oxygen and water, iron oxidizes in the acidic environment. The key point here is to disperse adequate amount of iron which is small enough in the biopolymer matrix. This will make hyperoxides to create hydroxy radicals. Superoxide-dependent formation of hydroxyl radicals are expected to damage DNA, proteins, lipids, and other cellular components. In our study the size of iron nanoparticles is small enough to penetrate into the bacteria. By manipulating dispersion conditions and iron concentration one could control the size of nano iron particles to develop the biomaterial as an anti cancer agent.

Biography :

Ayben Kilislioglu received her Master of Science degree in physical chemistry from IU in 1994. She received her doctor of philosophy degree in physical chemistry from IU in 2000. She worked as visiting research Assistant Professor at the University of Illinois, Chicago, department of chemistry, between 2005-2006. She also worked at University of Chicago in Dr. Graeme Bell?s Lab in 2007. She has research experience in adsorption, surface characterization and ion exchange. She worked on different projects funded by Istanbul University Grant Commission. She has published several research articles and a book chapter in this area. She is currently working in the department of chemistry, Istanbul University in Turkey.