Development of guided tissue regeneration/guided bone regeneration membranes for periodontal regeneration

4^th International Conference and Exhibition on Materials Science & Engineering

September 14-16, 2015 Orlando, USA

Asma Tufail1, 2

1COMSATS Institute of Information Technology (CIIT), Pakistan 2University of Sheffield, UK

Posters-Accepted Abstracts: J Material Sci Eng

Abstract :

Periodontitis is the gum infection that degrades the four tooth-supporting tissues of the periodontium, i.e., gingiva, periodontal ligament, cementum and bone. The rate of periodontal breakdown has significantly increased in patients since last few years. Recent therapies are unable to totally regenerate all four tissues. Guided Tissue Regeneration (GTR) and Guided Bone Regeneration (GBR) are techniques being used extensively for treatment of periodontitis. In both these cases, an occlusive periodontal membrane acts as a barrier to prevent epithelial and connective tissues down-growth into the defect and thus enables periodontal regeneration. Existing membranes suffer from problems like unpredictable resorption time, heterogeneity, microbial attack, low mechanical strength, difficult to handle, high price and unacceptability by patients. GTR/GBR membranes have been synthesized using bioactive ceramic material (bioactive glass) with composition of SiO2: CaO: P2O5 with polymers chitosan, alginate and PCL. Kaolin and bentonite clays have been used in these membranes to increase their stability and mechanical properties. The membranes have been prepared by freeze drying and electrospinning techniques. The synthesized membranes were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Brunauer-Emmett-Teller (BET) surface area analyzer, X-Ray Diffraction (XRD) and Thermogravimetric Analysis-Differential Scanning Calorimetry (TGA-DSC). Results indicate that both structural and thermal properties of membranes are highly influenced by addition of clays. The addition of clay can control the swelling rate and degradation rate by altering the pore to volume ratio, which further improves the mechanical stability. The biological and physical characterization revealed that the fabricated membrane possesses excellent biological and mechanical properties.

Biography :

Email: asmashah_buct@yahoo.com