Development of sustained release tablet of verapamil HCl using natural polymers

2^nd International Conference and Exhibition on Pharmaceutical Regulatory Affairs

November 23-24, 2012 Hyderabad International Convention Centre, India

T. A. Mullani, D. A. Bhagwat, A. K. Mullani and J. I. D?Souza

Posters: Pharmaceut Reg Affairs

Abstract :

Advancement in development of sustained-release drug delivery systems is use of polymer of natural origin to fulfill the aim of sustaining the drug release. Aim of present study was to develop sustained release tablet of Verapamil HCl using natural polymers such as Locust bean gum (LBG) and Xanthan gum (XG). Different batches of SR tablet were prepared using various concentrations of LBG, XG and combination of both. Prepared tablets were evaluated for various parameters like hardness, friability, uniformity of weight, uniformity of drug content, swelling behavior, drug-polymer interaction, in-vitro drug release and short term stability studies. In-vitro drug release studies were performed using USP XXIII apparatus-I at 100 rpm. The results of in-vitro drug release showed that as concentration of polymer increases drug release retardation also increase. It was also found that formulations containing Xanthan gum retard more drug than that of formulation containing Locust bean gum. Formulation containing combination of both LBG and XB showed required drug release which was compared with marketed formulation. It was may be due to synergistic effect of both polymer. Short term stability study of optimized formulation showed that formulation was stable at respective temperature and humidity condition. Study concluded that it is possible to make once a day sustained release tablet of Verapamil HCl using natural polymer such as Locust bean gum and Xanthan gum

Biography :

Tabassum A. Mullani is post graduate student of Department of Pharmaceutics, Tatyasaheb Kore College of Pharmacy, Warananagar affiliated with Shivaji University Kolhapur.