Distribution of HLA-B*58:01 association with allopurinol-induced SCARs in thai population

14^th World Conference on Human Genomics and Genomic Medicine

August 26, 2021 | Webinar

Subunya Jaroenjiengchai

Bodindecha (Sing Singhaseni), Thailand

Scientific Tracks Abstracts: J Mol Genet Med

Abstract :

Allopurinol is the most commonly used for treatment in patients with gouty arthritis, hyperuricemia and cancer patients undergoing chemotherapy. However, allopurinol is a major cause of severe cutaneous adverse reactions (SCARs) in Europeans, Asians, and Thais. We found that the HLA-B*58:01 is associated with allopurinol-induced SCARs including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia and systemic symptoms (DRESS) in many populations. Furthermore, the frequency of HLA-B*58:01 allele has interested for the screening among different ethnicities before initiation of treatment. To study the frequency of HLA-B*58:01 with Allopurinol-induced SCARs in Thai population. 200 general Thai population who had no history of drug-induced SCARs were included in this study. HLA-B alleles were genotyped using polymerase chain reaction-sequence-specific oligonucleotides (PCR-SSOs). Among all 200 subjects in Thais, the top five of HLA-B alleles consisted of HLA-B*46:01 (16.00%), HLA-B*40:01(8.00%), HLA-B*15:02 (7.25%), HLA-B*13:01 (6.50%), and HLA-B*58:01 (6.25%). Moreover, HLA-B*58:01 allele was the highest allele in the Asian population approximately 7.38%. On the contrary, we found this allele approximately 1.13% of Caucasians, 1.07% of Hispanics, and 0.80% of North American. Interestingly, HLA-B*58:01 was the main allele in Thailand and there was found more common in African Americans (6.37%). Our pharmacogenomics database could be used as a screening test for other populations before treatment with allopurinol.

Biography :

Subunya Jaroenjiengchai is a student of Bodindecha (Sing Singhaseni) school. I am interested in medical field and want to study medicne in Thai university. This research will be a the part of my portfolio which is a visual representation of my activities and experiences.