Dose time of presentation of patients of severe sepsis determines the clinical outcome?

2^nd World Congress on Biomarkers & Clinical Research

12-14 September 2011 Baltimore, USA

Fahad Aziz

Scientific Tracks Abstracts: J Mol Biomark Diagn

Abstract :

T he aim of this study was to compare the outcomes of patients with septic shock (SS) over a 12-month Period in a closed MICU setting, presenting during diff erent times of the day. Methods: Patients admitted to the medical intensive care unit (MICU) between January 2009 to January 2010 of a tertiary care center, who fulfi lled the already reported consensus criteria for septic shock were included in this study. Results: A total of 100 patients admitted to MICU with the diagnosis of SS were included in this study. Patients were divided into four groups on the basis of their presentation time (Group 1: 6AM-11:59 AM, Group 2: 12:00 PM- 5:59 PM, Group 3: 6PM-11:59PM & Group 4: 12:00 AM- 5:59 AM). Th e mean age of cohort was 66.75 yr with 60% males. No signifi cant diff erences were noted among the four groups with the respect to age, gender, hypertension, CAD, DM and COPD (P not signifi cant). Th e clinical out comes in the four groups were compared in terms of need for ventilator & inotropic support, number of deaths and length of stay of the patients in the MICU among diff erent groups. Th e patients in group A i.e. between 6 AM-11: 59 AM were found to have worse out come as compared to the patients in group B, C and D. Discussion: Th e main fi nding of this retrospective study is that patients admitted to MICU in the morning hours have worse prognosis, as compared to the patients admitted during the rest of the days. A change in the organizational/staffi ng structure of a closed MICU during the early morning likely explains the increased mortality noted. It is likely that a number of factors in combination, including the morning rounds account for the higher risk of death during the morning hours. Our study showed that the patients with septic shock follow the same circadian rhythm in respect to their all-clinical out comes. Th e patients presented in fi rst quadrant i.e. between 6AM-11: 59 AM had worse out come as compared to the other patients presenting in the other quadrants. Conclusion: Th e data suggests that septic shock patients presenting early in the day have worse prognosis as compared to the patients presenting late during the day.

Biography :

Dr. Aziz is currently working as Internal Medicine resident at Jersey City Medical Center/ Mount Sinai School of Medicine. In addition to being an outstanding researcher, Dr. Aziz has authored several articles on different topics of his research and is working right now on many important research projects related to Critical Care medicine and Cardiology. These articles have also been cited hundreds of times by other researchers in the fi eld. Dr. Aziz has presented his fi ndings at various medical conferences and published in several internationally read peer-reviewed journals. In addition to that he is a member of editorial board of several well-recognized journal. His work has been well recognized both nationally and internationally.