Drug hunting vs. drug fishing

6^th World Congress on Medicinal Chemistry and Drug Design

June 07-08, 2017 Milan, Italy

Youssef L Bennani

Vertex Pharmaceuticals, Canada

Posters & Accepted Abstracts: Med Chem (Los Angeles)

Abstract :

The presentation will cover the difference between drug hunting and drug fishing. This will be illustrated by two drug discovery efforts aimed at identifying antiviral and antibiotic clinical agents. Namely, we have discovered azaindole-based molecule acting through a novel mechanism targeting the influenza virus, which led to a clinically effective agent VX-787. The second part will cover efforts aimed at solving medicinally relevant bio-transformations, which can limit progress of clinical molecules, as we discovered a new and pharmacologically effective class of antibiotics, VX-100.

Biography :

Email: Youssef_Bennani@vrtx.com