Dual system of ex vivo lung perfusion: Describing Shehata model

4^th Global Surgery and Transplantation Congress

October 03-04, 2016 Atlanta, USA

Mohamed Shehata

Essen University Hospital, Germany

Posters & Accepted Abstracts: J Transplant Technol Res

Abstract :

Due to the increased incidence of end stage lung diseases, lung transplantation has become a frequent intervention that constitutes the sole therapeutic strategy. Unfortunately, up to 80% of the available lung grafts could not be considered for transplantation. The introduction of ex vivo lung perfusion (EVLP) technique allowed the reconditioning of the otherwise declined grafts, which had a significant impact on the clinical outcome and the mortality within the waiting lists of the patients. Moreover, the value of reconstruction of the bronchial arteries during lung transplantation was previously documented, where it was found to protect the pulmonary endothelium and type II pneumocytes in the early phase after transplantation. The bronchial blood flow was also found to be important for the vitality of the airways, the fluid balance of pulmonary tissue and the metabolic functions of the lungs. Accordingly, the inclusion of the bronchial arteries in the ex vivo lung graft perfusion has been suggested to provide a significant functional improvement. Currently, there are only two dual EVLP systems that have been described; an experimental dual- EVLP system, which was designed for the ex vivo perfusion of rat heart-lung blocks and the Shehata- described model. The results of the experimental study confirmed the expected significant impact on the graft physiology and histology, including the attenuation of the cytokine production. The other (Shehata) model differs from the experimental model in the technique of the inclusion of bronchial arteries in the perfusion circuit.

Biography :

Email: mohammed.shehatta1@gmail.com