Effect of bone marrow-derived mesenchymal stem cells combined with vitamin E on inflammatory reaction in acute kidney injury

9^th International Conference on Nephrology: Kidney & Therapeutics

September 29-30, 2016 Orlando, USA

Zhao Lei, Yuan Jing and Chen Xin

Second Clinical Medical College of Jinan University, China

Posters & Accepted Abstracts: J Nephrol Ther

Abstract :

Aim of this study was to explore the effect of bone marrow-derived mesenchymal stem cells (BMSCs) combined with vitamin E on the inflammatory reaction in acute kidney injury (AKI) in rats. Gentamicin was used to induce AKI in the rats and the rats were treated with BMSCs combined with vitamin E. After treatment, the rat plasma and kidney tissues were collected and the inflammatory proteins were detected by real time quantitative PCR and ELISA. After the treatment with BMSCs combined with vitamin E, the inflammatory proteins were down-regulated in the plasma and the renal tissues. Compared with single treatment group, the decrease in the inflammatory proteins were more obviuos in combined treatment group. The method of BMSCs combined with vitamin E takes the anti-inflammatory effect on AKI, indicating a new and potential mode in clinical application for AKI therapy.

Biography :

Email: zhaoleicx@126.com