Effect of Lavandula officinalis on thyroid hormones in mice Balb/C

5^th International Conference on Organic and Inorganic Chemistry

July 12-13, 2018 | Paris, France

Saeed Arefian

Payame Noor University, Iran

Posters & Accepted Abstracts: J Chemical Sci

Abstract :

Lavandula officinalis is a plant with many unknown effects on organism physiology. Previous articles about it were focused on some available and routine effects on brain and not specifically about other physiological realities. This study examines effect of hydro alcoholic extract on thyroid hormones. In this study 50 mature female mice Balb/C were applied. It was treated with Lavandula officinalis hydro alcoholic extract in three doses like 50, 100 and 200 mg/kg and two groups of them were control group without any injection and placebo group with normal saline injection. After 20 days (10 times every other day) in head guillotine way, blood was taken. Gained blood samples were kept in laboratory condition for 20 minutes and were centrifuged for 15 minutes with 2000 rpm. After that, serum of every tube has separated and TSH, T3 and T4 were measured by SYSMEX�© autoanalyzer apparatus. Data were analyzed with SPSS and Excel software and t-student test. Significant difference between experimental and control groups considered with P value, Pâ�¤0.05. The results indicated that lavender hydro alcoholic extract has increased some thyroid hormones and it was proved that thyroxine (T4) hormone was increased compared with control group and the extract has caused hyperthyroidism. The research results can be a significant step in order to realize the usage of this plant in therapeutic purposes and the most important result is main compound of the extract i.e. 3, 7-dimethylocta-1, 6-dien-3-yl acetate (linalyl acetate) and the biochemical effects of this compound on organisms.