Jihane Chaibat
Ibn Tofail University, Morocco
Posters & Accepted Abstracts: J Neurol Disord
The main objective of this work is to study the effect of lead acetate on behavior of anxiety and depression in male and female Wistar rats. The experimental study is carried out on young rats of a number of 40, the animals are divided into 4 batches experimental, control batch and 3 batches exposed to successive doses of 0.25 mg / kg, 0.5 mg / kg and 1mg / kg of lead acetate. The metal is administered daily at 4:00 p.m. by injection under cutaneous and for a period of 8 weeks. At the end of the various treatments, the animals were subjected to the open field test (OFT), the raised cross maze test (EPM) for determine the level of anxiety and the forced swimming test to elucidate the level of depression. The results obtained showed that anxiety and depression behaviors are clearly expressed in rats poisoned by lead acetate, suggesting that this metal induces anxiogenic and depressive effects. In addition, the acuteness of depression and anxiety is accentuated, however, as the concentration of lead increases, which reveals the effect of dependent. Our results confirm that lead causes side effects behavioral issues such as anxiety and depression.
Neurological Disorders received 1343 citations as per Google Scholar report
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