Effect of saponin from Solanum anguivi on heart function of alloxan induced diabetic rats

Joint Event on 14^th World Summit on Alzheimer’s Disease, Dementia Care Research and Awareness & 6^th World Summit on Heart, Stroke and Neurological Disorders

August 31- September 01, 2018 | Boston, USA

Oladepo Mutiu Lolade, Babatunde Joshua Otunla and Ayodele Jacob Akinyemi

Adekunle Ajasin University, Nigeria
Joseph Ayo Babalola University, Nigeria
Afe Babalola University, Nigeria

Posters & Accepted Abstracts: J Neurol Disord

Abstract :

Solanum anguivi is a semi-domestic indigenous vegetable very valuable in many African countries with potential to become a cultivated market vegetable in Nigeria. Uptake of Solanum anguivi cause hypoglycemic effect, hypertension e.t.c. The effect of Saponin from Solanum anguivi on heart function of an alloxan-induced diabetic rat was investigated in this Study. Twenty four (24) rats of average weight 120g were randomly divided into six (6) groups A-F. Group A (control) rats were given 2.0ml of distilled water, Group B (Diabetic control), Group C to F were diabetic rats which were administered 20mg/ kg, 40mg/kg and 80mg/kg Saponin from Solanum anguivi respectively for 14 days. The results showed that there was a significant reduction in plasma glucose in the diabetic rat to almost the level in the Control. The result also shows that there were a significant reduction in Aspartate Aminotransferase AST and Alanine aminotransferase ALT activities in serum and heart compared with the control (p<0.05). This study shows that Solanum anguivi fruit has an anti-diabetic effect on alloxan induced diabetic rat.

Biography :

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