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Effects of Bifidobacterium breve feeding strategy and delivery modes on experimental allergic rhinitis mice
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Medical Microbiology & Diagnosis

ISSN: 2161-0703

Open Access

Effects of Bifidobacterium breve feeding strategy and delivery modes on experimental allergic rhinitis mice


JOINT EVENT ON 15th International PHARMACEUTICAL MICROBIOLOGY AND BIOTECHNOLOGY CONFERENCE & 10th Annual MEDICAL MICROBIOLOGY SUMMIT & EXPO

June 21-23, 2017 London, UK

Ren Jian-jun, Yu Zhao, Feng-Ling Yang, Dan LV, Shi Hung, Jie Zhang, Ping Lin, Shi-Xi Liu, Nan Zhang and Claus Bachert

Sichuan University, China
Ghent University, Belgium

Posters & Accepted Abstracts: J Med Microb Diagn

Abstract :

Background: Different delivery modes may affect the susceptibility to allergic diseases. It is still unknown whether early intervention with probiotics would counteract this effect. Aim: The effect of different delivery modes on immune status and nasal symptoms was investigated on established allergic rhinitis (AR) mouse model. In addition, the immuno-regulatory effects and mechanisms of different feeding manners with Bifidobacterium breve (B. breve) were examined. Methods: Live lyophilized B. breve was orally administered to BALB/c mice born via vaginal delivery (VD) or cesarean delivery (CD) for eight consecutive weeks, after which they were sensitized by ovalbumin (OVA) to establish experimental AR. Nasal symptoms, serum immuno-globulins, cytokines, splenic percentages of CD4+CD25+Foxp3+ regulatory T (Treg) cells and nasal eosinophil infiltration were evaluated. Results: Compared with VD mice, mice delivered via CD demonstrated more serious nasal symptoms, higher concentrations of OVA-specific immunoglobulin (Ig) E, more nasal eosinophil and lower percentages of splenic CD4+CD25+Foxp3+Treg cells after establishing experimental AR. These parameters were reversed by administering B. breve shortly after birth. However, the effect of B. breve did not differ between different delivery modes. Conclusion: CD aggravates the nasal symptoms of AR mice compared to VD. This is the first report that oral administration of B. breve shortly after birth can significantly alleviate the symptoms of AR mice born via both deliveries, probably via activation of the regulatory capacity of CD4+CD25+Foxp3+Treg cells.

Biography :

Email: renjianjun237@163.com

Google Scholar citation report
Citations: 14

Medical Microbiology & Diagnosis received 14 citations as per Google Scholar report

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