Effects of Cervi cornus Colla (deer antler glue) on reconstructing skin equivalents

International Conference on Tissue Science & Engineering

October 1-3, 2012 DoubleTree by Hilton Chicago-North Shore, USA

Hyo-Soon Jeong, Jandi Kim, Hailan Li, Kwang Jin Baek, Nyoun Soo Kwon, Hye-Young Yun, Hye-Ryung Choi, Kyoung-Chan Park and Dong-Seok Kim

Posters: J Tissue Sci Eng

Abstract :

T he aim of this study was to investigate the effects of Cervi cornus Colla (CCC) on skin equivalent (SE) formation. H&E staining showed that SEs containing hyaluronic acid (HA) or HA & CCC had a thicker epidermis than the control. Immunohistochemical staining showed that p63 was mainly present at the basal layer of epidermis in the HA & CCC model. Involucrin was obviously expressed in the upper layer of the epidermis in the HA & CCC model. Moreover, we observed that integrins α6 and β1 were strongly expressed in the basement membrane zone of the HA & CCC model. In the HA & CCC model, the dermis expressing type 1 collagen was more compact. In conclusion, our data indicate that CCC contributed the formation of epidermis, basement membrane, and extracellular matrix in reconstructing SEs, and suggest that CCC may be a useful adjuvant for producing SEs

Biography :

Hyo-Soon Jeong received her PhD from the Keimyung University School of Medicine (Korea) in 2003. She is working as a postdoctoral fellow in the Department of Biochemistry at the Chung-Ang University College of Medicine. For a period of two years her work involves bioartificial skin and signaling pathways of hyperpigmentation in melanocytes