Effects of some natural compounds on the Glutathione reductase enzyme

9^th Annual European Pharma Congress

June 26-28, 2017 Madrid, Spain

Tuba Aydin, Murat Senturk and Ahmet Cakir

Agri Ibrahim Cecen University, Turkey
Kilis 7 Aralik University, Turkey

Scientific Tracks Abstracts: Pharmaceut Reg Affairs

Abstract :

Discovery of Glutathione Reductase (GR) inhibitors has become very popular recently due to antimalarial and anticancer activities. In this study, GR inhibitory capacities of some natural compounds, �²-sitosterol, �²-stigmasterol, diosgenin and jervine, which have steroidal skeleton, were reported. While �²-stigmasterol was isolated from Artemisia dracunculus, �²-sitosterol, diosgenin and jervine were isolated from rhizomes of Veratrum album. The chemical structures of the compounds were confirmed by IR, 1H-NMR, 13C-NMR, 1D and 2D NMR methods. The tested molecules were exhibited much potent inhibitory activities against GR at low micromolar concentrations with IC50 values ranging from 0.1916 to 5.2116 �¼M as compared with well-known agents. In this study first time, the inhibition effects of �²-sitosterol, �²-stigmasterol, diosgenin and jervine were determined on glutathione reductase enzyme.

Biography :

Tuba Aydin is currently working as an Assistant Professor in the Faculty of Pharmacy at the Agri Ibrahim Cecen University, Turkey where she has been a faculty member since 2013. She completed her PhD at Ataturk University, Turkey. She has expertise in isolation and characterization of phytochemicals from natural products.

Email: aydintuba25@gmail.com